Autologous vs Allogenic Cell Therapies
What are cell based therapies?
Cell based therapies are a form of regenerative medicine that involves leveraging cells to repair, rejuvenate or replace diseased and damaged tissues to improve the patients health. This promising avenue of therapeutics has two types of cell sources: allogeneic, using donor cells and autologous, using a patient’s own cells. There are very specific uses for each cell type, as well as some notable limitations and risks that we’ll cover in this article.
Allogeneic cell therapies
Allogeneic therapies use cells collected from a donor sample. There are significant risks of immune rejection when allogeneic cell therapies are used. For that reason, immunosuppressive therapies are given in combination with allogeneic treatments, which means that there is a higher risk of infection and other complications that arise from weakening the immune system. Some of the complications could include graft-versus-host disease or rejection of the donor cells. However, there are some instances where your own cell population is compromised and donor cells and tissues are required.
Allogeneic cells may also be leveraged with immune privileged tissues. These tissues are able to tolerate introduction of cells and tissues that are not an identical match to the recipient. One example of this includes the eye, which limits local immune reaction to preserve vision.
Autologous cell therapies
Autologous therapies use the cells derived from the patient’s own body. While processes can vary, the patient's cells are first collected, then they are cultured and expanded outside of the body and reintroduced into the donor. Using a patient's own cell source means they have cells genetically matched to their bodies and won’t have to worry about the adverse immune reactions that could come with using donor cells. Additionally, there would be no need for immunosuppressive therapies as the cell source is identical to you and your genetics. And when it comes to aesthetic treatments like skin and hair, autologous treatments will match the unique colours and tones in appearance. Learn more about autologous cell therapies approved in Canada.
Having a bank of your own cells to leverage in cell based therapies means that you won’t have to worry about adverse reactions from allogeneic cell sources.
Learn more about getting banked here.
Can Adults Bank Stem Cells?
What if we told you that babies are not the only ones with stem cells and that this powerful cell type also exists in adults? This article will help you identify various stem cell sources, evaluate stem cell usefulness, explore harvesting and storage methods, and illustrate how they could be used in the future.
Why We Bank the Hair Follicle
The hair follicle is valuable source of cells which can be used in regenerative medicine like the creation of 3D tissue grafts for wound healing, rejuvenating aged skin, or creating neurons. The therapeutic potential is becoming incrementally clear to researchers. Learn more about why we bank the hair follicle here.